Johannes Roth Selected Research

Sepsis (Septicemia)

2/2023	Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State.
12/2022	Associations of Betatrophin/ANGPTL8 with Septic Dyslipidemia in Human Peritonitis: An Explorative Analysis.
12/2020	S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
1/2018	Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis.
1/2017	In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock.
1/2017	S100-alarmin-induced innate immune programming protects newborn infants from sepsis.
12/2014	Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
9/2013	S100A12 and soluble receptor for advanced glycation end products levels during human severe sepsis.
6/2013	Proinflammatory S100A12 can activate human monocytes via Toll-like receptor 4.
7/2012	Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages.

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Johannes Roth Research Topics

Disease

69	Inflammation (Inflammations) 12/2023 - 11/2002
26	Infections 03/2024 - 04/2004
23	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 07/2023 - 09/2003
22	Arthritis (Polyarthritis) 01/2023 - 06/2003
17	Neoplasms (Cancer) 01/2023 - 08/2005
15	Sepsis (Septicemia) 02/2023 - 10/2005
6	Rheumatoid Arthritis 12/2019 - 06/2003
6	Rheumatic Diseases (Rheumatism) 01/2019 - 07/2007
5	Contact Dermatitis (Eczema, Contact) 12/2022 - 03/2007
5	Vasculitis (Vasculitides) 01/2022 - 09/2004
5	Osteoarthritis 09/2019 - 05/2012
5	Necrosis 01/2016 - 08/2005
4	Breast Neoplasms (Breast Cancer) 01/2023 - 11/2008
4	Pain (Aches) 01/2023 - 01/2014
4	Synovitis 01/2023 - 05/2005
4	Peritonitis 12/2022 - 12/2009
4	Granuloma 12/2022 - 06/2007
4	Pneumonia (Pneumonitis) 11/2022 - 05/2007
4	Osteoporosis 11/2021 - 08/2007
4	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 09/2003
4	Experimental Arthritis 01/2018 - 11/2010
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2016 - 11/2005
4	Shock 04/2015 - 09/2007
4	Hypersensitivity (Allergy) 08/2014 - 03/2007
4	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 12/2007 - 04/2003
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2023 - 01/2016
3	Lung Injury 01/2023 - 01/2013
3	Septic Shock (Toxic Shock Syndrome) 01/2021 - 12/2014
3	Neoplasm Metastasis (Metastasis) 12/2020 - 01/2017
3	Wounds and Injuries (Trauma) 01/2018 - 10/2012
3	Acute Lung Injury 01/2017 - 05/2007
3	Joint Diseases (Joint Disease) 10/2016 - 12/2005
3	Human Influenza (Influenza) 01/2014 - 10/2009
3	Cryopyrin-Associated Periodic Syndromes 12/2011 - 12/2008
2	Leukemia 10/2023 - 04/2015
2	Nephrotic Syndrome (Syndrome, Nephrotic) 10/2023 - 04/2015
2	Virus Diseases (Viral Diseases) 02/2023 - 11/2008
2	Familial Mediterranean Fever (Periodic Disease) 01/2023 - 04/2010
2	Crohn Disease (Crohn's Disease) 01/2023 - 03/2015
2	Urinary Tract Infections (Urinary Tract Infection) 01/2022 - 09/2013
2	Tonsillitis 09/2021 - 06/2021
2	Bacterial Infections (Bacterial Infection) 06/2021 - 01/2018
2	Diabetes Mellitus 01/2021 - 12/2015
2	Peritonsillar Abscess 01/2021 - 01/2017
2	Psoriatic Arthritis 01/2021 - 06/2003
2	Cystic Fibrosis (Mucoviscidosis) 01/2021 - 01/2020

Drug/Important Bio-Agent (IBA)

47	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2003
30	AlarminsIBA 01/2023 - 09/2009
28	Biomarkers (Surrogate Marker)IBA 01/2023 - 06/2004
19	CytokinesIBA 12/2022 - 10/2009
16	Toll-Like Receptor 4IBA 01/2023 - 09/2007
15	S100A12 ProteinIBA 12/2015 - 04/2003
13	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2021 - 11/2002
13	S100 Proteins (S 100 Protein)IBA 12/2020 - 06/2003
11	LigandsIBA 01/2023 - 12/2007
9	GlucocorticoidsIBA 10/2023 - 01/2012
7	CalciumIBA 12/2022 - 06/2004
6	Methotrexate (Mexate)FDA LinkGeneric 09/2022 - 06/2003
6	AntigensIBA 01/2018 - 06/2003
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2013 - 05/2005
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 10/2005
5	Interleukin-1 (Interleukin 1)IBA 01/2021 - 01/2010
5	EndotoxinsIBA 04/2015 - 09/2007
5	Receptor for Advanced Glycation End ProductsIBA 01/2015 - 04/2003
4	Messenger RNA (mRNA)IBA 12/2022 - 11/2005
4	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 10/2010
4	InterleukinsIBA 01/2021 - 12/2011
4	C-Reactive ProteinIBA 01/2021 - 10/2005
4	Pattern Recognition ReceptorsIBA 01/2019 - 10/2005
4	ChemokinesIBA 04/2014 - 01/2013
4	Matrix Metalloproteinases (MMPs)IBA 08/2011 - 11/2003
3	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 07/2023 - 10/2016
3	Insulin (Novolin)FDA Link 12/2022 - 02/2017
3	Irritants (Vesicants)IBA 12/2022 - 01/2018
3	Peroxidase (Myeloperoxidase)IBA 01/2022 - 10/2010
3	Antigen-Antibody Complex (Immune Complex)IBA 01/2022 - 11/2003
3	tocilizumab (atlizumab)FDA Link 10/2021 - 04/2014
3	Interleukin-17 (Interleukin 17)IBA 01/2020 - 06/2010
3	AutoantibodiesIBA 01/2020 - 09/2005
3	Peptides (Polypeptides)IBA 01/2018 - 06/2014
3	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2017 - 07/2007
3	Interleukin-8 (Interleukin 8)IBA 12/2015 - 10/2005
3	Calcium-Binding ProteinsIBA 01/2015 - 04/2003
3	EnzymesIBA 05/2014 - 12/2007
3	LipopolysaccharidesIBA 08/2013 - 10/2009
2	InflammasomesIBA 12/2023 - 07/2012
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 07/2023 - 12/2011
2	Imiquimod (Aldara)FDA LinkGeneric 01/2023 - 01/2020
2	PyrinIBA 01/2023 - 11/2015
2	LipidsIBA 12/2022 - 12/2020
2	SteroidsIBA 11/2021 - 04/2015
2	Interleukin-18 (Interleukin 18)IBA 06/2021 - 01/2020
2	Vitamin D FDA LinkGeneric 01/2021 - 01/2012
2	paquinimodIBA 01/2021 - 07/2015
2	Rheumatoid FactorIBA 01/2021 - 01/2016

Therapy/Procedure

26	Therapeutics 09/2023 - 08/2005
3	Critical Care (Surgical Intensive Care) 09/2023 - 01/2021
3	Biological Therapy 07/2023 - 09/2012
2	Operative Surgical Procedures 09/2021 - 01/2018
2	Tonsillectomy 09/2021 - 06/2021